VER-82576

VER-82576 (NVP-BEP800) is a potent, orally available and selective Hsp90 inhibitor, with an IC50 of 58 nM for Hsp90β; VER-82576 also slightly blocks Grp94 and Trap-1, with IC50s of 4.1 and 5.5 μM, respectively.

Product Specifications

CAS Number

[847559-80-2]

Product Name Alternative

NVP-BEP800

UNSPSC

12352005

Hazard Statement

H317, H319

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NVP-BEP800.html

Purity

98.76

Solubility

DMSO : 6.2 mg/mL (ultrasonic)

Smiles

O=C(C1=CC2=C(N=C(N=C2S1)N)C3=CC(OCCN4CCCC4)=C(C=C3Cl)Cl)NCC

Molecular Formula

C21H23Cl2N5O2S

Molecular Weight

480.41

Precautions

H317, H319

References & Citations

[1]Massey AJ, et al. Preclinical antitumor activity of the orally available heat shock protein 90 inhibitor NVP-BEP800. Mol Cancer Ther. 2010 Apr;9 (4) :906-19.|[2]Niewidok N, et al. Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity. Transl Oncol. 2012 Oct;5 (5) :356-69. Epub 2012 Oct 1.|[3]Wu J, et al. Irradiation facilitates the inhibitory effect of the heat shock protein 90 inhibitor NVP-BEP800 on the proliferation of malignant glioblastoma cells through attenuation of the upregulation of heat shock protein 70. Exp Ther Med. 2014 Sep;8 (3) :893-898. Epub 2014 Jun 23.