TEAD-IN-9
TEAD-IN-9 (compound 17) is a TEAD1 inhibitor with an IC50 of 0.29 μM. TEAD-IN-9 targets the palmitoyl pocket of TEAD, thereby effectively inhibiting the binding of YAP-TEAD and blocking the transcriptional function of YAP-TEAD[1].
Product Specifications
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tead-in-9.html
Solubility
10 mM in DMSO
Smiles
O=P(C)(C)C1=CC=C(NCC2=CC=C(C(F)(F)F)C=C2)C(C3=NC(OC4COC4)=CC=N3)=C1
Molecular Formula
C23H23F3N3O3P
Molecular Weight
477.42
References & Citations
[1]Dong Liu. Small molecule compound having phosphorylated aryl structure, and use thereof. WO2024061366A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD
Frequently Asked Questions
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