ZAP70 Active Protein Human

<strong>ZAP70 Active Protein Human</strong>_x000D_ <strong>Catalog number:</strong> B2013495_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 96 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> SRK, STD, TZK, zeta-chain (TCR) associated protein kinase 70 kDa_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Leveille E, Chan LN, Mirza AS, Kume K, M√ɬºschen M. SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies Cell Signal. 2022 Jun;94:110331._x000D_ 2: Sadras T, Martin M, Kume K, Robinson ME, Saravanakumar S, Lenz G, Chen Z, Song JY, Siddiqi T, Oksa L, Knapp AM, Cutler J, Cosgun KN, Klemm L, Ecker V, Winchester J, Ghergus D, Soulas-Sprauel P, Kiefer F, Heisterkamp N, Pandey A, Ngo V, Wang L, Jumaa H, Buchner M, Ruland J, Chan WC, Meffre E, Martin T, M√ɬºschen M. Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer Mol Cell. 2021 May 20;81(10):2094-2111.e9._x000D_ 3: Hauck F, Blumenthal B, Fuchs S, Lenoir C, Martin E, Speckmann C, Vraetz T, Mannhardt-Laakmann W, Lambert N, Gil M, Borte S, Audrain M, Schwarz K, Lim A, Schamel WW, Fischer A, Ehl S, Rensing-Ehl A, Picard C, Latour S. SYK expression endows human ZAP70-deficient CD8 T cells with residual TCR signaling Clin Immunol. 2015 Dec;161(2):103-9._x000D_ 4: Thurm C, Poltorak MP, Reimer E, Brinkmann MM, Leichert L, Schraven B, Simeoni L. A highly conserved redox-active Mx(2)CWx(6)R motif regulates Zap70 stability and activity Oncotarget. 2017 May 9;8(19):30805-30816._x000D_ 5: Pugh JL, Nemat-Gorgani N, Norman PJ, Guethlein LA, Parham P. Human NK Cells Downregulate Zap70 and Syk in Response to Prolonged Activation or DNA Damage J Immunol. 2018 Feb 1;200(3):1146-1158._x000D_ 6: B√ɬ©n√ɬ© MC. What is ZAP-70? Cytometry B Clin Cytom. 2006 Jul 15;70(4):204-8._x000D_ 7: Au-Yeung BB, Shah NH, Shen L, Weiss A. ZAP-70 in Signaling, Biology, and Disease Annu Rev Immunol. 2018 Apr 26;36:127-156._x000D_ 8: Fischer A, Picard C, Chemin K, Dogniaux S, le Deist F, Hivroz C. ZAP70: a master regulator of adaptive immunity Semin Immunopathol. 2010 Jun;32(2):107-16._x000D_ 9: Amin S, Walsh M, Wilson C, Parker AE, Oscier D, Willmore E, Mann D, Mann J. Cross-talk between DNA methylation and active histone modifications regulates aberrant expression of ZAP70 in CLL J Cell Mol Med. 2012 Sep;16(9):2074-84._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/9833479">10: Okawa H. [Severe combined immunodeficiency] Ryoikibetsu Shokogun Shirizu. 1998;(21 Pt 2):235-9.</a>_x000D_ _x000D_ <strong>Products Related to ZAP70 Active Protein Human can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>