Magic™ Membrane Protein Human CXCR4 (C-X-C motif chemokine receptor 4)

Human CXCR4 (C-X-C Chemokine Receptor type 4) is an α-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. CXCR4 is essential for proper fetal development and is the major co-receptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1). Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. As most N-terminal domain of chemokine receptors are the ligand binding domain, the N-terminal domain of CXCR4 is the binding site for SDF-1.