Glutamate Dehydrogenase (Bovine Liver)

<strong>Glutamate Dehydrogenase (Bovine Liver)</strong>_x000D_ <strong>Catalog number:</strong> B2010234_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 20 mg_x000D_ <strong>pH:</strong> na_x000D_ <strong>Supplied as:</strong> Ready-to-use_x000D_ <strong>Appearance:</strong> Lyophilized Powder_x000D_ <strong>Applications:</strong> high purity (95%), high specific activity (19U/mg) freeze-dried powder of Glutamate Dehydrogenase (GLDH), a mitochondrial enzyme that catalyzes the oxidative deamination of glutamate into α-ketoglutarate._x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> GLDH, GDH, Glutamate Dehydrogenase_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 99%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered on a 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Smith HQ, Li C, Stanley CA, Smith TJ. Glutamate Dehydrogenase, a Complex_x000D_ Enzyme at a Crucial Metabolic Branch Point. Neurochem Res. 2019_x000D_ Jan;44(1):117-132._x000D_ _x000D_ 2: Craze ML, El-Ansari R, Aleskandarany MA, Cheng KW, Alfarsi L, Masisi B, Diez-_x000D_ Rodriguez M, Nolan CC, Ellis IO, Rakha EA, Green AR. Glutamate dehydrogenase_x000D_ (GLUD1) expression in breast cancer. Breast Cancer Res Treat. 2019_x000D_ Feb;174(1):79-91._x000D_ _x000D_ 3: Jin Y, Li D, Lu S, Zhao H, Chen Z, Hou W, Ruan BH. Ebselen Reversibly_x000D_ Inhibits Human Glutamate_Dehydrogenase at the Catalytic Site. Assay Drug Dev_x000D_ Technol. 2018 Feb/Mar;16(2):115-122._x000D_ _x000D_ 4: Li M, Li C, Allen A, Stanley CA, Smith TJ. Glutamate dehydrogenase:_x000D_ structure, allosteric regulation, and role in insulin homeostasis. Neurochem_x000D_ Res. 2014;39(3):433-45._x000D_ _x000D_ 5: Plaitakis A, Zaganas I, Spanaki C. Deregulation of glutamate_dehydrogenase in_x000D_ human neurologic disorders. J Neurosci Res. 2013 Aug;91(8):1007-17._x000D_ _x000D_ 6: Spanaki C, Plaitakis A. The role of glutamate_dehydrogenase in mammalian_x000D_ ammonia metabolism. Neurotox Res. 2012 Jan;21(1):117-27._x000D_ _x000D_ 7: Hull J, Usmari Moraes M, Brookes E, Love S, Conway ME. Distribution of the_x000D_ branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate_x000D_ dehydrogenase in the human brain and their role in neuro-metabolism. Neurochem_x000D_ Int. 2018 Jan;112:49-58._x000D_ _x000D_ 8: Shashidharan P, Plaitakis A. The discovery of human of GLUD2 glutamate_x000D_ dehydrogenase and its implications for cell function in health and disease._x000D_ Neurochem Res. 2014;39(3):460-70._x000D_ _x000D_ 9: Tomita T, Yin L, Nakamura S, Kosono S, Kuzuyama T, Nishiyama M. Crystal_x000D_ structure of the 2-iminoglutarate-bound complex of glutamate_dehydrogenase from_x000D_ Corynebacterium glutamicum. FEBS Lett. 2017 Jun;591(11):1611-1622._x000D_ _x000D_ 10: Smith TJ, Stanley CA. Untangling the glutamate_dehydrogenase allosteric_x000D_ nightmare. Trends Biochem Sci. 2008 Nov;33(11):557-64._x000D_ _x000D_ 11: Nassar OM, Wong KY, Lynch GC, Smith TJ, Pettitt BM. Allosteric_x000D_ discrimination at the NADH/ADP regulatory site of glutamate_dehydrogenase._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31610054/">Protein Sci.</a> 2019 Dec;28(12):2080-2088._x000D_ _x000D_ <strong>Products Related to Glutamate Dehydrogenase (Bovine Liver)</strong><a>: Biochemical Buffers and Solutions</a>