PAβN (dihydrochloride)

PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

Product Specifications

CAS Number

[100929-99-5]

Product Name Alternative

MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride

UNSPSC

12352209

Hazard Statement

H350

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/PA_beta_N_dihydrochloride.html

Purity

99.89

Solubility

DMSO : 83.33 mg/mL (ultrasonic) |H2O : 14.29 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCNC(N)=N)NC([C@H](CC1=CC=CC=C1)N)=O)NC2=CC(C=CC=C3)=C3C=C2.Cl.Cl

Molecular Formula

C25H32Cl2N6O2

Molecular Weight

519.47

Precautions

H350

References & Citations

[1]Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45 (1) :105-16.|[2]Kurin?i? M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18 (5) :492-501.|[3]Lamers RP, et al. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013;8 (3) :e60666.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Al-Rafidain Journal of Medical Sciences. 2025 Feb 11.|bioRxiv. 2020 Apr.|Cell Rep. 2025 Jul 22;44 (7) :115987. |Front Cell Infect Microbiol. 2021 Mar 25;11:660431.|Front Microbiol. 2024 Sep 24:15:1417237.|J Antimicrob Chemother. 2021 Dec 24;77 (1) :58-68.|Microb Drug Resist. 2020 Jun;26 (6) :550-560.|Microb Pathog. 2023 Dec:185:106397.|Microbiol Spectr. 2025 Sep 2;13 (9) :e0114425.|mSphere. 2023 Apr 20;8 (2) :e0067322.|World J Microbiol Biotechnol. 2024 Jun 6;40 (8) :233.|ACS Infect Dis. 2024 Feb 9;10 (2) :541-552.|Microbiol Spectr. 2023 Jun 15;11 (3) :e0308022.