UCL-1848 (TFA)
Product Specifications
UNSPSC Description
UCL-1848 TFA is a hSK1 blocker with an IC50 value of 1.1 nM. hSK1 is a small conductance calcium-activated potassium channel[1].
Target Antigen
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ucl-1848-tfa.html
Smiles
O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.C1(NCCCCCNC2=C3C=CC=CC3=[N+]4C=C2)=CC=[N+](CCCCC4)C5=CC=CC=C15
Molecular Weight
652.63
References & Citations
[1]Shah M, et al. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129(4):627-30.|[2]Chen JQ, et al. bis-Quinolinium cyclophanes: 8,14-diaza-1,7(1, 4)-diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca(2+)-activated K(+) channel. J Med Chem. 2000 Sep 21;43(19):3478-81.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-122104/UCL-1848-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-122104/
Clinical Information
No Development Reported
CAS Number
201147-53-7
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