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UCL-1848 (TFA)

UCL-1848 TFA is a hSK1 blocker with an IC50 value of 1.1 nM. hSK1 is a small conductance calcium-activated potassium channel[1].

Product Specifications

CAS Number

[201147-53-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ucl-1848-tfa.html

Smiles

O=C([O-])C(F)(F)F.O=C([O-])C(F)(F)F.C1(NCCCCCNC2=C3C=CC=CC3=[N+]4C=C2)=CC=[N+](CCCCC4)C5=CC=CC=C15

Molecular Formula

C32H34F6N4O4

Molecular Weight

652.63

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Shah M, et al. The pharmacology of hSK1 Ca2+-activated K+ channels expressed in mammalian cell lines. Br J Pharmacol. 2000 Feb;129 (4) :627-30.|[2]Chen JQ, et al. bis-Quinolinium cyclophanes: 8,14-diaza-1,7 (1, 4) -diquinolinacyclotetradecaphane (UCL 1848), a highly potent and selective, nonpeptidic blocker of the apamin-sensitive Ca (2+) -activated K (+) channel. J Med Chem. 2000 Sep 21;43 (19) :3478-81.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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