Quinine (hydrobromide)

Quinidine hydrobromide is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine hydrobromide is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine hydrobromide can be used for malaria research[1][2][3].

Product Specifications

CAS Number

[549-49-5]

UNSPSC

12352005

Hazard Statement

H302-H312-H315-H317-H319-H332-H334-H335

Target

Cytochrome P450; Parasite; Potassium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/quinine-hydrobromide.html

Solubility

10 mM in DMSO

Smiles

O[C@H](C1=CC=NC2=C1C=C(OC)C=C2)[C@@]3([H])[N@](C[C@@H]4C=C)CC[C@H]4C3.[H]Br

Molecular Formula

C20H25BrN2O2

Molecular Weight

405.33

Precautions

P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Kehl SJ, et al. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[2]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide.