CORM-3
CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].
Product Specifications
CAS Number
475473-26-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/corm-3.html
Purity
97.5
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O
Molecular Formula
C5H4ClNO5Ru
Molecular Weight
294.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142 (3) :453-60.|[2]Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493 (2) :957-963.|[3]Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2) -induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Available Sizes
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