CORM-3

CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation[1][2][3].

Product Specifications

CAS Number

[475473-26-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

NF-κB; NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/corm-3.html

Purity

97.5

Solubility

DMSO : 75 mg/mL (ultrasonic)

Smiles

O#C[Ru+2](C#O)([Cl-])([O-]C1=O)([N]([H])([H])C1)C#O

Molecular Formula

C5H4ClNO5Ru

Molecular Weight

294.61

Precautions

H302, H315, H319, H335

References & Citations

[1]Foresti R, et al. Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol. 2004 Jun;142 (3) :453-60.|[2]Lee DW, et al. Carbon monoxide regulates glycolysis-dependent NLRP3 inflammasome activation in macrophages. Biochem Biophys Res Commun. 2017 Nov 18;493 (2) :957-963.|[3]Huang Y, et al. Carbon monoxide (CO) inhibits hydrogen peroxide (H2O2) -induced oxidative stress and the activation of NF-κB signaling in lens epithelial cells. Exp Eye Res. 2018 Jan;166:29-39.