Methacycline (hydrochloride)

Methacycline hydrochloride is a tetracycline antibiotic and can inhibits bacterial protein synthesis. Methacycline hydrochloride is a potent epithelial-mesenchymal transition (EMT) inhibitor. Methacycline hydrochloride blocks EMT in vitro and fibrogenesis in vivo without directly affecting TGF-β1 Smad signaling. Methacycline hydrochloride is an antimicrobial and has the potential for pulmonary fibrosis[1].

Product Specifications

CAS Number

[3963-95-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H350, H360

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Methacycline-hydrochloride.html

Purity

99.71

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 6.67 mg/mL (ultrasonic)

Smiles

O[C@@](C(O)=C(C(C1=C2C=CC=C1O)=O)[C@](C2=C)([H])[C@@H]3O)(C(C(C(N)=O)=C4O)=O)[C@]3([H])[C@@H]4N(C)C.Cl

Molecular Formula

C22H23ClN2O8

Molecular Weight

478.88

Precautions

H315, H319, H335, H350, H360

References & Citations

[1]Ying Xi, et al. Inhibition of epithelial-to-mesenchymal transition and pulmonary fibrosis by methacycline. Am J Respir Cell Mol Biol. 2014 Jan;50 (1) :51-60.