[D-Trp8]-Somatostatin

<strong>[D-Trp8]-Somatostatin</strong> <strong>Catalog number:</strong> MDP0473 <strong>CAS Number: </strong>106362-32-7 <strong>Sequence: </strong>Ala-Gly-Cys-Lys-Asn-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-Ser-Cys (Disulfide bond between Cys3-Cys14) <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 1637.6 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Vécsei L, Bollók I, Penke B, Telegdy G. Somatostatin and (D-Trp8, D-Cys14)-somatostatin delay extinction and reverse electroconvulsive shock induced amnesia in rats Psychoneuroendocrinology. 1986;11(1):111-5. 2: Felix AM, Jimenez MH, Wang CT, Meienhofer J. Synthesis of somatostatin and [D-Trp8]-somatostatin Int J Pept Protein Res. 1980 Apr;15(4):342-54. 3: Dokas LA, Klis M, Liauw A, Coy DH. Characteristics of [D-Trp8]-somatostatin-sensitive B50 phosphorylation Peptides. 1985 Nov-Dec;6(6):1101-7. 4: Rivier J, Brown M, Vale W. D-Trp8-somatostatin: an analog of somatostatin more potent than the native molecule Biochem Biophys Res Commun. 1975 Jul 22;65(2):746-51. 5: Chernish SM, Miller RE, Rosenak BD, Brunelle RL. Effect of D-Val1, D-Trp8-somatostatin on the motility of the stomach, duodenum and jejunum Am J Gastroenterol. 1981 Jan;75(1):36-40. 6: Neelamkavil S, Arison B, Birzin E, Feng JJ, Chen KH, Lin A, Cheng FC, Taylor L, Thornton ER, Smith AB 3rd, Hirschmann R. Replacement of Phe6, Phe7, and Phe11 of D-Trp8-somatostatin-14 with L-pyrazinylalanine. Predicted and observed effects on binding affinities at hSST2 and hSST4. An unexpected effect of the chirality of Trp8 on NMR spectra in methanol J Med Chem. 2005 Jun 16;48(12):4025-30. 7: Cohen ML, Wiley KS, Yaden E, Slater IH. In vitro actions of somatostatin, D-Val1, D-Trp8-somatostatin and glucagon in rabbit jejunum and guinea-pig ileum J Pharmacol Exp Ther. 1979 Nov;211(2):423-9. 8: Epelbaum J, Bluet-Pajot MT, Llorens-Cortes C, Kordon C, Mounier F, Senut MC, Videau C. 125I-[Tyr0,D-Trp8]somatostatin-14 binding sites in the locus coeruleus of the rat are located on both ascending and descending projecting noradrenergic cells Peptides. 1990 Jan-Feb;11(1):21-7. 9: Brown M, Rivier J, Vale W. Somatostatin: analogs with selected biological activities Science. 1977 Jun 24;196(4297):1467-9. <a href="https://pubmed.ncbi.nlm.nih.gov/966246">10: Rivier JE, Brown MR, Vale WW. Tyrosylated analogues of somatostatin J Med Chem. 1976 Aug;19(8):1010-3. </a> <br><strong>Products Related to [D-Trp8]-Somatostatin can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>