Ruxolitinib
Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3[1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy[3].
Product Specifications
CAS Number
[941678-49-5]
Product Name Alternative
INCB18424
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; Autophagy; JAK; Mitophagy
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ruxolitinib.html
Purity
99.99
Solubility
H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC[C@H](C1CCCC1)N2N=CC(C3=C4C=CNC4=NC=N3)=C2
Molecular Formula
C17H18N6
Molecular Weight
306.37
Precautions
H302
References & Citations
[1]Quintas-Cardama A, et al. Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasms. Blood, 2010, 115 (15), 3109-3117.|[2]Verstovsek S, et al. A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosis. N Engl J Med, 2012, 366 (9), 799-807.|[3]Tavallai M, et al. Rationally Repurposing Ruxolitinib (Jakafi (®) ) as a Solid Tumor Therapeutic.Front Oncol. 2016 Jun 13;6:142.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
JAK1; JAK2; JAK3; Tyk2
Citation 01
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