PPTN (hydrochloride)

PPTN hydrochloride is a potent, high-affinity, competitive and highly selective P2Y14 receptor antagonist with a KB value of 434 pM. PPTN hydrochloride exhibits no agonist or antagonist effect at the P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, or P2Y13 receptors. Anti-inflammatory and anti-immune activity[1].

Product Specifications

CAS Number

[1992047-65-0]

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/pptn-hydrochloride.html

Purity

99.89

Solubility

DMSO : 66.67 mg/mL (adjust pH to 11 with 1 M NaOH)

Smiles

FC(F)(C1=CC=C(C2=CC=C3C(C4=CC=C(C=C4)C5CCNCC5)=CC(C(O)=O)=CC3=C2)C=C1)F.Cl

Molecular Formula

C29H25ClF3NO2

Molecular Weight

511.96

References & Citations

[1]Barrett MO, et al. A selective high-affinity antagonist of the P2Y14 receptor inhibits UDP-glucose-stimulated chemotaxis of human neutrophils. Mol Pharmacol. 2013 Jul;84 (1) :41-9.|[2]Lin J, et al. The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain. Neurochem Int. 2019 Dec;131:104567.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P2Y14 Receptor

Citation 01

Clin Immunol. 2024 Jun 29:110300.|Neuropharmacology. 2025 Oct 14:110723.|Cell Rep. 2025 Nov 18;44 (12) :116577.|Int Immunopharmacol. 2023 Jan:114:109507.