(-) -U-50488 (hydrochloride)

(-) -U-50488 hydrochloride ((-) -Trans- (1S,2S) -U-50488 hydrochloride) is a selective kappa-opioid receptor (KOR) agonist (b>Kd=2.2 nM) over μ-opioid receptor (MOR) (b>Kd=430 nM) . (-) -U-50488 hydrochloride is a more active enantiomer than (+) trans- (1R,2R) U-50488 (HY-15997A) or the (±) trans-racemic mixture U-50488 (HY-15997B) . (-) -U-50488 hydrochloride has a potent and sustained anti-HIV effect in fected blood monocyte-derived macrophages (MDM) [1].

Product Specifications

CAS Number

[114528-79-9]

Product Name Alternative

(-) -Trans- (1S,2S) -U-50488 (hydrochloride)

UNSPSC

12352005

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/minus-u-50488-hydrochloride.html

Purity

99.71

Solubility

DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N(C)[C@@H]1[C@@H](N2CCCC2)CCCC1)CC3=CC=C(Cl)C(Cl)=C3.[H]Cl

Molecular Formula

C19H27Cl3N2O

Molecular Weight

405.79

References & Citations

[1]Kirti Kumari Sharma, et al. The search for the "next" euphoric non-fentanil novel synthetic opioids on the illicit drugs market: current status and horizon scanning. Forensic Toxicol. 2019;37 (1) :1-16.|[2]Anthony S Zannas, ET AL. Regulation and function of MeCP2 Ser421 phosphorylation in U50488-induced conditioned place aversion in mice. Psychopharmacology (Berl) . 2017 Mar;234 (6) :913-923.|[3]C C Chao, et al. U50488 inhibits HIV-1 expression in acutely infected monocyte-derived macrophages. Drug Alcohol Depend. 2001 Apr 1;62 (2) :149-54.