Crotalicidin

Crotalicidin is an antimicrobial peptide and anti-tumor peptide that can effectively inhibit the activity of Gram-negative bacteria and tumor cells. Crotalicidin can be obtained from rattlesnake venom. Crotalicidin can be used in the study of microbial infections and cancer[1].

O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@H]([C@@H](C)CC)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC(CNC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H]3N(C([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC4=CC=CC=C4)NC([C@H]([C@@H](C)CC)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CO)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](C(C)C)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC5=CC=CC=C5)NC([C@H](CC6=CC=CC=C6)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CC7=CC=CC=C7)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC3)=O)=O)=O)=O)=O)=O)=O)=O)CCC2)=O

[1]Falcao CB, et al. Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity. J Med Chem. 2015 Nov 12;58(21):8553-63.