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L-Ascorbic acid

L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition enhancer and an elastogenesis inhibitor[1][2][3]. L-Ascorbic acid exhibits anti-cancer effects through the generation of reactive oxygen species (ROS) and selective damage to cancer cells[4].

Product Specifications

CAS Number

[50-81-7]

Product Name Alternative

L-Ascorbate; Vitamin C

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Calcium Channel; Endogenous Metabolite; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/L-Ascorbic-acid.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

Smiles

OC([C@@]1([H])[C@H](CO)O)=C(O)C(O1)=O

Molecular Formula

C6H8O6

Molecular Weight

176.12

Precautions

H302, H315, H319, H335

References & Citations

[1]Sebastian J Padayatty, et al. Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22 (1) :18-35.|[2]Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27 (46) :12577-83.|[3]Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75 (3) :173-82.|[4]Sungrae Cho, et al. Hormetic dose response to L-ascorbic acid as an anti-cancer drug in colorectal cancer cell lines according to SVCT-2 expression. Sci Rep. 2018 Jul 27;8 (1) :11372.|[5]Satyanarayana Sreemantula, et al. Influence of antioxidant (L- ascorbic acid) on tolbutamide induced hypoglycaemia/antihyperglycaemia in normal and diabetic rats. BMC Endocr Disord. 2005 Mar 3;5 (1) :2.

Shipping Conditions

Room Temperature

Storage Conditions

RT, protect from light

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Microbial Metabolite; T-type calcium channel

Citation 01

ACS Nano. 2025 Mar 18;19 (10) :10180-10198.|Adv Mater. 2024 Dec 26:e2415543.|Anim Biotechnol. 2024 Nov;35 (1) :2404043.|Antioxid Redox Signal. 2020 Dec 10;33 (17) :1191-1208.|Antioxidants (Basel) . 2024 May 27;13 (6) :653.|Biochem Biophys Res Commun. 2024 May 14:708:149770.|Biol Methods Protoc. 2025 Feb 13;10 (1) :bpaf012.|Biol Pharm Bull. 2025;48 (6) :895-907.|Biomaterials. 2024 Aug 15:313:122756.|Biomed Pharmacother. 2022 Sep:153:113558.|Bioorg Chem. 2021 Oct:115:105177.|Bioorg Chem. 2024 May:146:107261.|Bioorg Chem. 2025 Jan 5:155:108133.|bioRxiv. 2025 August 25.|Biosci Rep. 2019 May 21;39 (5) :BSR20182137.|Bone Res. 2025 Mar 3;13 (1) :30.|Cancer Cell Int. 2024 May 31;24 (1) :192.|Cancer Cell. 2024 Apr 8;42 (4) :682-700.e12.|Cell Biol Toxicol. 2023 Jun;39 (3) :679-702.|Cell Cycle. 2023 Feb;22 (4) :476-493.|Cell Host Microbe. 2024 Dec 12:S1931-3128 (24) 00444-X.|Clin Exp Pharmacol Physiol. 2024 Nov;51 (11) :e13923.|Cytotechnology. 2021 Dec;73 (6) :787-800.|Drug Chem Toxicol. 2024 May;47 (3) :347-355.|Eur J Med Chem. 2022 Mar 5:231:114151.|Fitoterapia. 2021 Sep:153:104984.|Food Biosci. 2025 Sep 18;73:107628.|Food Funct. 2022 May 10;13 (9) :5089-5101.|Free Radic Biol Med. 2020 Feb 1;147:220-230.|Front Cell Dev Biol. 2022 Feb 10:10:810327.|Genes (Basel) . 2024 Sep 13;15 (9) :1206.|Ind Crops Prod. 2025 Oct 18;237:122143.|Int J Biol Macromol. 2024 Jan;256 (Pt 1) :127779.|Int J Biol Macromol. 2025 May 15:144179.|Int J Mol Sci. 2025 Feb 5;26 (3) :1334.|iScience. 2024 Feb 5;27 (3) :109111.|IUBMB Life. 2024 Oct;76 (10) :832-844.|J Adv Res. 2025 May 10:S2090-1232 (25) 00309-1.|J Agric Food Chem. 2025 Jun 4;73 (22) :13891-13901.|J Biol Chem. 2023 Dec;299 (12) :105462.|J Cell Mol Med. 2020 Apr;24 (7) :4212-4222.|J Cell Physiol. 2024 May;239 (5) :e31215.|J Ethnopharmacol. 2024 Nov 29:340:119128.|J Mol Histol. 2024 Aug;55 (4) :503-512.|J Nat Prod. 2022 Jul 22;85 (7) :1808-1815.|J Neuroinflammation. 2025 Sep 24;22 (1) :211.|J Neurosci Res. 2019 Dec;97 (12) :1689-1705.|J Orthop Surg Res. 2025 Apr 15;20 (1) :379.|J Orthop Surg Res. 2025 Nov 14;20 (1) :997.|J Orthop Surg Res. 2025 Oct 29;20 (1) :943.|J Pharmacol Toxicol Methods. Nov-Dec 2020;106:106913.|J Sex Med. 2018 Feb;15 (2) :136-147. |Mater Today Bio. 2025 Jun 21:33:102009.|Mol Biol Rep. 2024 Mar 14;51 (1) :421.|Mol Med Rep. 2019 Dec; 20 (6) : 4933–4942.|Mol Pharmacol. 2025 Sep 28.|Nat Immunol. 2023 Feb;24 (2) :280-294.|Nigerian Journal of Scientific Research. 18 (3) : 2019.|Oxid Med Cell Longev. 2022 Jan 27:2022:7502632.|Redox Biol. 2022 Aug;54:102392.|Redox Rep. 2024 Dec;29 (1) :2428147.|Res Sq. 2025 Jul 21.|Res Sq. 2025 Oct 27.|Research Square Print. 2022 Aug.|Sci China Life Sci. 2018 Oct;61 (10) :1151-1167.|SSRN. 2025 Jan 14.|Environ Toxicol. 2021 Apr;36 (4) :520-529.|FASEB J. 2020 Sep;34 (9) :11474-11487.|Hematol Oncol. 2024 Jul;42 (4) :e3295.|J Afr Ass Physiol Sci. 7 (1) : 30-37, July 2019.|Med Rev (2021) . 2024 Jun 14;4 (6) :531-543.|Mil Med Res. 2020 Nov 1;7 (1) :52.|Nat Commun. 2025 Jul 18;16 (1) :6621.

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