Rabbit anti Human Calcium Homeostasis Modulator Protein 1

CALHM1 controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration. It controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca2+ dependent manner. However, no association between CALHM1 and AlzheimerÕs risk is unclear. Member of the FAM26 family of proteins. CALHM1 is predominantly expressed in the adult brain. It has also been detected in retinoic acid-differentiated SH-SY5Y cells. Also colocalizes with HSPA5 at the endoplasmic reticulum.

Antibody can be used for Western Blotting (1:400 dilution) and immunohistochemistry (2-10 µg/mL). Optimal concentration should be evaluated by serial dilutions.

This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

1. Dreses-Werringloer, U., et la. A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Ab Levels, and Alzheimer’s Disease Risk. Cell 2008, 133, 1149-1161 2. Bertram, L., et al. 'No association between CALHM1 and Alzheimer’s disease risk.' Cell 2008, 135(6), 993-994. 3. Cui, P.J., et al. 'CALHM1 P86L polymorphism is a risk for Alzheimer’s Disease in the Chinese population.' J. Alzheimers Dis. 2009, Epub ahead of