SMARCA2-IN-4

SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1 (5), SMARCA2B and SMARCA4 with Kd of 124, 262 and 417 nM[1].

Product Specifications

CAS Number

[1915012-19-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/smarca2-in-4.html

Smiles

CN(CC1)CCN1/C=C2CCN(C\2=N3)C4=CC=CC(Cl)=C4C3=O

Molecular Formula

C17H19ClN4O

Molecular Weight

330.81

References & Citations

[1]Sutherell CL, et al., Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5 (1H) -one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J Med Chem. 2016 May 26;59 (10) :5095-101.