SMARCA2-IN-4
SMARCA2-IN-4 (Compound 26) is an inhibitor for SWI/SNF chromatin remodeling complexe SMARCA by targeting the bromodomains. SMARCA2-IN-4 exhibits high affinity for PB1 (5), SMARCA2B and SMARCA4 with Kd of 124, 262 and 417 nM[1].
Product Specifications
CAS Number
1915012-19-9
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smarca2-in-4.html
Smiles
CN(CC1)CCN1/C=C2CCN(C\2=N3)C4=CC=CC(Cl)=C4C3=O
Molecular Formula
C17H19ClN4O
Molecular Weight
330.81
References & Citations
[1]Sutherell CL, et al., Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5 (1H) -one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J Med Chem. 2016 May 26;59 (10) :5095-101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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