HyT36
Product Specifications
UNSPSC Description
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3[1][2][3].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hyt36.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClCCCCCCOCCOCCNC([C@H](C)CCC1(C[C@H]2C3)C[C@H]3C[C@H](C2)C1)=O
Molecular Weight
442.07
References & Citations
[1]Tae HS, et al. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem. 2012 Mar 5;13(4):538-41.|[2]Rubner S, et al. Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells. Org Biomol Chem. 2019 Mar 20;17(12):3113-3117. |[3]Neklesa TK, et al. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem Biol. 2013 Oct 18;8(10):2293-2300.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-141676/HyT36-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-141676/
Clinical Information
No Development Reported
CAS Number
1323151-45-6
Available Sizes
Curated Selection
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