HyT36
HyT36 is a low molecular weight hydrophobic tag that promotes the degradation of fusion protein and pseudokinase Her3[1][2][3].
Product Specifications
CAS Number
1323151-45-6
UNSPSC
12352211
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hyt36.html
Purity
96.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClCCCCCCOCCOCCNC([C@H](C)CCC1(C[C@H]2C3)C[C@H]3C[C@H](C2)C1)=O
Molecular Formula
C25H44ClNO3
Molecular Weight
442.07
References & Citations
[1]Tae HS, et al. Identification of hydrophobic tags for the degradation of stabilized proteins. Chembiochem. 2012 Mar 5;13 (4) :538-41.|[2]Rubner S, et al. Poloxin-2HT+: changing the hydrophobic tag of Poloxin-2HT increases Plk1 degradation and apoptosis induction in tumor cells. Org Biomol Chem. 2019 Mar 20;17 (12) :3113-3117. |[3]Neklesa TK, et al. A bidirectional system for the dynamic small molecule control of intracellular fusion proteins. ACS Chem Biol. 2013 Oct 18;8 (10) :2293-2300.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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