BIO-8169
BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu, u of 0.7[1].
Product Specifications
CAS Number
[2792153-06-9]
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bio-8169.html
Solubility
10 mM in DMSO
Smiles
CC(OC1=NC2=NC(C34COC(C3)(C4)C)=CN2C=C1C(NC5=CC=CN(C5=O)C6CC6)=O)C
Molecular Formula
C24H27N5O4
Molecular Weight
449.50
References & Citations
[1]Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67 (10) :8383-8395.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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