BIO-8169
Product Specifications
UNSPSC Description
BIO-8169 is a selective inhibitor for interleukin receptor-associated kinase 4 (IRAK 4), with an IC50 of 0.23 nM. BIO-8169 exhibits good pharmacokinetic character, reduces the production of pro-inflammatory cytokines, and attenuates the autoimmune encephalomyelitis in EAE mice model. BIO-8169 exhibits good blood brain penetrant with a rat Kpu,u of 0.7[1].
Target Antigen
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bio-8169.html
Solubility
10 mM in DMSO
Smiles
CC(OC1=NC2=NC(C34COC(C3)(C4)C)=CN2C=C1C(NC5=CC=CN(C5=O)C6CC6)=O)C
Molecular Weight
449.50
References & Citations
[1]Pfaffenbach M, et al., Discovery of BIO-8169─A Highly Potent, Selective, and Brain-Penetrant IRAK4 Inhibitor for the Treatment of Neuroinflammation. J Med Chem. 2024 May 23;67(10):8383-8395.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-158374/BIO-8169-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-158374/
Clinical Information
No Development Reported
CAS Number
2792153-06-9
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