Trans-Isoferulic acid-d3

Trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) [3].

Product Specifications

CAS Number

[1028203-97-5]

UNSPSC

12352005

Target

NO Synthase; Prostaglandin Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Solubility

10 mM in DMSO

Smiles

OC(/C=C/C(C=C1)=CC(O)=C1OC([2H])([2H])[2H])=O

Molecular Formula

C10H7D3O4

Molecular Weight

197.20

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kai-Hui Sun, et al. A new indole-type alkaloid from the roots of < i> Clematis florida var. plena< /i> . Nat Prod Res. 2019 Oct;33 (20) :2925-2931.|[3]Matharage Gayani Dilshara, et al. Downregulation of NO and PGE2 in LPS-stimulated BV2 microglial cells by trans-isoferulic acid via suppression of PI3K/Akt-dependent NF-κB and activation of Nrf2-mediated HO-1. Int Immunopharmacol. 2014 Jan18 (1) :203-11.