Tebanicline (dihydrochloride)
Tebanicline dihydrochloride (Ebanicline dihydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. It inhibits the binding of cytisine to α4β2 neuronal nAChRs with a Ki of 37 pM[1].
Product Specifications
CAS Number
209326-19-2
Product Name Alternative
Ebanicline (dihydrochloride) ; ABT-594 (dihydrochloride)
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Tebanicline__hydrochloride_.html
Purity
99.49
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
[H]Cl.ClC(C=C1)=NC=C1OC[C@@H]2NCC2.[H]Cl
Molecular Formula
C9H13Cl3N2O
Molecular Weight
271.57
References & Citations
[1]Donnelly-Roberts DL, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.J Pharmacol Exp Ther. 1998 May;285 (2) :777-86.|[2]Bannon AW, et al. ABT-594 [ (R) -5- (2-azetidinylmethoxy) -2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285 (2) :787-94.|[3]Decker MW, et al. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice. Eur J Pharmacol. 1998 Apr 3;346 (1) :23-33.|[4]Decker MW, et al. The role of neuronal nicotinic acetylcholine receptors in antinociception: effects of ABT-594. J Physiol Paris. 1998 Jun-Aug;92 (3-4) :221-4.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
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