R406 (free base)
Product Specifications
UNSPSC Description
R406 free base is an orally available and competitive Syk/FLT3 inhibitor for ATP binding with a Ki of 30 nM, potently inhibits Syk kinase activity in vitro with an IC50 of 41 nM, measured at an ATP concentration corresponding to its Km value. R406 free base reduces immune complex-mediated inflammation[1]. R406 free base also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[2].
Target Antigen
Apoptosis; FLT3; Syk
Type
Reference compound
Related Pathways
Apoptosis;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/R406-free-base.html
Purity
99.80
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
COC1=CC(NC2=NC(NC3=NC(N4)=C(C=C3)OC(C)(C)C4=O)=C(C=N2)F)=CC(OC)=C1OC
Molecular Weight
470.45
References & Citations
[1]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.|[2]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8.Adv Mater. 2024 Mar 15:e2311283.|Harvard Medical School LINCS LIBRARY|iScience. 2024 Jan 8.|Mater Today Bio. 2024 Mar 22, 101037.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|SSRN. 2023 Jun 29.|ACS Infect Dis. 2021 Mar 12;7(3):661-671.|Ann Transl Med. 2019 Dec;7(23):758.|Arthritis Rheumatol. 2018 Sep;70(9):1419-1428. |Atherosclerosis. 2019 Oct;289:132-142.|bioRxiv. 2022 Dec 21, 519945.|bioRxiv. 2024 Apr 9.|Blood Adv. 2024 Nov 12;8(21):5653-5662.|BMC Cardiovasc Disord. 2024 Jul 12;24(1):354.|Cell Commun Signal. 2024 Apr 2;22(1):210.|Cell Rep. 2023 Mar 20;42(3):112275.|Cell. 2018 Oct 4;175(2):442-457.e23.|Exp Hematol Oncol. 2022 Nov 8;11(1):88.|Front Pharmacol. 2022 May 5;13:885053.|iScience. 2024 June 28.|iScience. 2024 Mar 25.|J Biol Chem. 2018 Apr 27;293(17):6410-6433.|J Pharmacol Sci. 2017 May;134(1):29-36.|Mol Immunol. 2024 Jul 31:173:88-98.|Nat Commun. 2022 Apr 19;13(1):2136.|Nihon University. School of Medicine. 2014 Mar.|Redox Biol. 3 September 2022, 102461.|Scand J Immunol. 2024 Apr 26:e13371.|Theranostics. 2021 May 24;11(15):7308-7321.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-11108/R406-free-base-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-11108/R406-free-base-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
841290-80-0
Available Sizes
Curated Selection
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