(5Z,2E)-CU-3
Product Specifications
UNSPSC Description
(5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
Target Antigen
Apoptosis; DGK
Type
Reference compound
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5z-2e-cu-3.html
Purity
98.04
Solubility
DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O
Molecular Weight
392.47
References & Citations
[1]Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-121638A/5Z-2E-CU-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-121638A/5Z-2E-CU-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1815598-71-0
Available Sizes
Curated Selection
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