Sudubrilimab
Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor II ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment[1].
Product Specifications
CAS Number
[2387417-06-1]
Product Name Alternative
HS636
UNSPSC
12352203
Target
PD-1/PD-L1
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sudubrilimab.html
Purity
99.27
Solubility
10 mM in DMSO
Smiles
[Sudubrilimab]
Molecular Weight
(144.3 kDa)
References & Citations
[1]Gao ZZ, et, al. Optimization strategies for expression of a novel bifunctional anti-PD-L1/TGFBR2-ECD fusion protein. Protein Expr Purif. 2022 Jan;189:105973.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6214538-01 0.1 mL
TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 550)
Ask
View Details 
MBS6214538-02 5x 0.1 mL
TRIM49 (Tripartite Motif-containing Protein 49, RING Finger Protein 18, Testis-specific RING-Finger Protein, RNF18) (MaxLight 550)
Ask
View Details 