FGFR2-IN-2
FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].
Product Specifications
CAS Number
2677709-81-6
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr2-in-2.html
Concentration
10mM
Purity
98.25
Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC=C(C2=CC3=C(C(C4=CC=C(N5CCNCC5)C=C4)=NN3)C=C2)C=C1
Molecular Formula
C23H22N4O
Molecular Weight
370.45
References & Citations
[1]Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65 (2) :1481-1504.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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