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FGFR2-IN-2

FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].

Product Specifications

CAS Number

2677709-81-6

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr2-in-2.html

Concentration

10mM

Purity

98.25

Solubility

DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=CC=C(C2=CC3=C(C(C4=CC=C(N5CCNCC5)C=C4)=NN3)C=C2)C=C1

Molecular Formula

C23H22N4O

Molecular Weight

370.45

References & Citations

[1]Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65 (2) :1481-1504.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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