Balovaptan

Balovaptan (RG7314) is an orally available, selective brain-penetrant vasopressin 1a (hV1a) receptor antagonist, with Kis of 1 and 39 nM for human (hV1a) and mouse (mV1a) receptors, and is used for the research of autism.

Product Specifications

CAS Number

[1228088-30-9]

Product Name Alternative

RG7314

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Balovaptan.html

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CN1CC2=NN=C([C@H]3CC[C@H](OC4=NC=CC=C4)CC3)[N@]2[C@]5=CC=C(Cl)C=C5C1

Molecular Formula

C22H24ClN5O

Molecular Weight

409.91

Precautions

H302, H315, H319, H335

References & Citations

[1]Ratni H, et al. Discovery of highly selective brain-penetrant vasopressin 1a antagonists for the potential treatment of autism via a chemogenomic and scaffold hopping approach. J Med Chem. 2015 Mar 12;58 (5) :2275-89.