A-65317
Product Specifications
UNSPSC Description
A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response[1][2].
Target Antigen
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a-65317.html
Smiles
O=C([C@@H](CC1=CNC=N1)NC([C@@H](CC(N(CCOCOCCOC)C)=O)CC2=CC=CC=C2)=O)N[C@H](C(O)[C@@H]3CN(C(O3)=O)CC)CC4CCCCC4
Molecular Weight
742.90
References & Citations
[1]K M Verburg, et al. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259(1 Pt 2):R7-14.|[2]Saul H. Rosenberg, et al. Renin Inhibitors. Integration of Pharmaceutical Discovery and Development Chapter pp 7-28.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-129607/A-65317-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-129607/
Clinical Information
No Development Reported
CAS Number
122224-84-4
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