A-65317

A-65317 is a primate-selective renin dipeptide inhibitor (IC50 of 0.37 nM) with long hypotensive response[1][2].

Product Specifications

CAS Number

[122224-84-4]

UNSPSC

12352005

Target

Renin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/a-65317.html

Smiles

O=C([C@@H](CC1=CNC=N1)NC([C@@H](CC(N(CCOCOCCOC)C)=O)CC2=CC=CC=C2)=O)N[C@H](C(O)[C@@H]3CN(C(O3)=O)CC)CC4CCCCC4

Molecular Formula

C38H58N6O9

Molecular Weight

742.90

References & Citations

[1]K M Verburg, et al. Effect of intrarenal renin inhibition on renal hemodynamics and excretory function. Am J Physiol. 1990 Jul;259 (1 Pt 2) :R7-14.|[2]Saul H. Rosenberg, et al. Renin Inhibitors. Integration of Pharmaceutical Discovery and Development Chapter pp 7-28.