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(Rac) -Efavirenz (Standard)

(Rac) -Efavirenz (Standard) is the analytical standard of (Rac) -Efavirenz. This product is intended for research and analytical applications. (Rac) -Efavirenz is the isomer of Efavirenz. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture[1].

Product Specifications

CAS Number

177530-93-7

Product Name Alternative

(Rac) -DMP 266 (Standard) ; (Rac) -EFV (Standard) ; (Rac) -L-743726 (Standard)

UNSPSC

12352005

Target

Autophagy; Endogenous Metabolite; HIV; Parasite; Reference Standards; Reverse Transcriptase

Type

Reference Standards

Related Pathways

Anti-infection; Autophagy; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/rac-efavirenz-standard.html

Smiles

O=C1OC(C2=CC(Cl)=CC=C2N1)(C(F)(F)F)C#CC3CC3

Molecular Formula

C14H9ClF3NO2

Molecular Weight

315.67

References & Citations

[1]Grobler JA, et al. HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro. J Biol Chem. 2007 Mar 16;282 (11) :8005-10.|[2]Young SD, et al. L-743, 726 (DMP-266) : a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase. Antimicrob Agents Chemother. 1995 Dec;39 (12) :2602-5.|[3]Held DM, et al. Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication. J Biol Chem. 2006 Sep 1;281 (35) :25712-22.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Frequently Asked Questions

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