PPAR agonist 4
PPAR agonist 4 (Compound 12) is an orally active agonist for peroxisome proliferator-activated receptor (PPAR), which activates PPARα, PPARδ and PPARγ with EC50s of 0.7, 0.7 and 1.8 μM, respectively. PPAR agonist 4 exhibits anti-liver fibrosis efficacy[1].
Product Specifications
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ppar-agonist-4.html
Solubility
10 mM in DMSO
Smiles
CC1=CC(CN2CCN(CC2)C3=NC=C(C=C3)C(F)(F)F)=CC(C)=C1OC(C)(C(O)=O)C
Molecular Formula
C23H28F3N3O3
Molecular Weight
451.48
References & Citations
[1]Sun G, et al., Design, synthesis, and biological evaluation of piperazine derivatives as pan-PPARs agonists for the treatment of liver fibrosis. Eur J Med Chem. 2024 Apr 5;269:116344.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ; PPARδ
Curated Selection
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