Uridine-5'-O- (3-thiotriphosphate)

Uridine-5'-O- (3-thiotriphosphate) (UTPγS), a stable analogue of Uridine triphosphate (UTP) (HY-107372), is a potent agonist of the P2Y2 and P2Y4 receptors with increased metabolic stability. Uridine-5'-O- (3-thiotriphosphate) stimulates inositol phosphate formation in human 1321N1 astrocytoma cells stably expressing the phospholipase C-coupled human P2U-purinoceptor (EC50 = 240 nM) [1][2][3].

Product Specifications

CAS Number

[79049-97-1]

Product Name Alternative

UTPγS

UNSPSC

12352005

Target

P2Y Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/uridine-5-o-3-thiotriphosphate.html

Smiles

O[C@H]1[C@@H](O)[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]1COP(OP(OP(O)(S)=O)(O)=O)(O)=O

Molecular Formula

C9H15N2O14P3S

Molecular Weight

500.21

References & Citations

[1]Anna-Karin Wihlborg, et al. Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. Circ Res. 2006 Apr 14;98 (7) :970-6.|[2]Malin Malmsjö, et al. The stable pyrimidines UDPβS and UTPγS discriminate between the P2 receptors that mediate vascular contraction and relaxation of the rat mesenteric artery. Br J Pharmacol. 2000 Sep;131 (1) :51-6.|[3]Lazarowski ER, et al. Enzymatic synthesis of UTP gamma S, a potent hydrolysis resistant agonist of P2U-purinoceptors. Br J Pharmacol. 1996 Jan;117 (1) :203-9.