CDK2/MDM2-IN-1
CDK2/MDM2-IN-1 (III-13) is a dual inhibitor of CDK2/MDM2 with an IC50 value of 2.60 nM for CDK2. CDK2/MDM2-IN-1 has antitumor activity[1].
Product Specifications
CAS Number
3083904-06-4
UNSPSC
12352005
Target
CDK; MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk2-mdm2-in-1.html
Solubility
10 mM in DMSO
Smiles
[H][C@]1(C2=CC(NC(CC3=CC=C(N4CCCC4=O)C=C3)=O)=NN2)CC[C@@H](OC(N5CCC5(C)C)=O)C1
Molecular Formula
C26H33N5O4
Molecular Weight
479.57
References & Citations
[1]Liu Z, et al. Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53. Molecules. 2024 Feb 4;29 (3) :725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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