Atelopidtoxin
Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel[1][2].
Product Specifications
CAS Number
9061-57-8
UNSPSC
12352005
Target
Sodium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/atelopidtoxin.html
Smiles
OC1([C@@]23[C@@]4([H])N(CN(C([C@@]4([H])N=C(N3C[C@]15C[C@](N(C(O5)=O)O)([H])[C@@H](CO)COS(=O)(O)=O)N)=O)O)C(N)=N2)O
Molecular Formula
C16H24N8O12S
Molecular Weight
552.47
References & Citations
[1]Yotsu-Yamashita M, et al. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. Proc Natl Acad Sci U S A. 2004 Mar 30;101 (13) :4346-51.|[2]Shindelman J, et al., Atelopidtoxin from the Panamanian frog, Atelopus zeteki. Toxicon. 1969 Dec;7 (4) :315-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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