A-176120
A-176120 is a selective inhibitor of farnesyl transferase (IC50=1.2 nM) based on a farnesyl pyrophosphate (FPP) analog, with superior selectivity against GGTaseI (IC50=423 nM), GGTaseII (IC50=3000 nM), and SSase (IC50>10 μM) . A-176120 inhibits ras processing in H-ras transformed NIH3T3 cells and HCT116 K-ras mutant cells (ED50=1.6 and 0.5 μM, respectively) . A-176120 has antiangiogenic and antitumor activities in vivo and reduces capillary structure formation and VEGF secretion[1].
Product Specifications
CAS Number
185049-54-1
UNSPSC
12352005
Target
Farnesyl Transferase; Ras; VEGFR
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-176120.html
Smiles
O=C(C1=CC(C(N(CC2=CC=CC=C2OCC)CC3=CC=CC(OC4=CC=C(C)C=C4)=C3)=O)=C(C(O)=O)C=C1C(O)=O)O
Molecular Formula
C33H29NO9
Molecular Weight
583.58
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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