PF-06442609
PF-06442609 is an orally active γ secretase modulator, with an IC50 of 6 nM for Aβ42. PF-06442609 possesses brain good penetration[1].
Product Specifications
CAS Number
1402002-76-9
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-06442609.html
Smiles
O=C1C(N2CCN1[C@@H](C)COC3=CC=C(F)C=C3[C@@H](C)C(F)(F)F)=CC=C(N4C=C(C)N=C4)C2=O
Molecular Formula
C24H24F4N4O3
Molecular Weight
492.47
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Martin Pettersson, et al. Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability. ACS Med Chem Lett. 2015 Apr 3;6 (5) :596-601.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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