BEC (hydrochloride)

BEC hydrochloride is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM and 30 nM at pH 7.5 and pH 9.5, respectively[1].

Product Specifications

CAS Number

[222638-67-7]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Arginase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/BEC-hydrochloride.html

Purity

98.0

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

N[C@@H](CSCCB(O)O)C(O)=O.[H]Cl

Molecular Formula

C5H13BClNO4S

Molecular Weight

229.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Colleluori DM, et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40 (31) :9356-62.|[2]Kim NN, et al. Probing erectile function: S- (2-boronoethyl) -L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40 (9) :2678-88.|[3]Ckless K, et al. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15;181 (6) :4255-64.