Dot1L-IN-8

Dot1L-IN-8 (Compound 15) is a potent Dot1L inhibitor. Dot1L-IN-8 inhibits HL-60, K562, MV4-11, HH, and KG-1 cells vitality with IC50s of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Histone Methyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dot1l-in-8.html

Smiles

NC1=C2N=CN(C2=NC=N1)[C@@H]3O[C@H](CN4CCC(CNCC5=CC(C6=CC=C(C(C)(C)C)C=C6)=C(C7=CC=C(C(C)(C)C)C=C7)S5)CC4)[C@@H](O)[C@H]3O

Molecular Formula

C41H53N7O3S

Molecular Weight

723.97

References & Citations

[1]Sethy B, et al. Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents. Bioorg Chem. 2024 Sep 6;153:107771.