Dot1L-IN-8
Dot1L-IN-8 (Compound 15) is a potent Dot1L inhibitor. Dot1L-IN-8 inhibits HL-60, K562, MV4-11, HH, and KG-1 cells vitality with IC50s of 0.45, 1.03, 0.68, 1.66, and 1.12 μM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dot1l-in-8.html
Smiles
NC1=C2N=CN(C2=NC=N1)[C@@H]3O[C@H](CN4CCC(CNCC5=CC(C6=CC=C(C(C)(C)C)C=C6)=C(C7=CC=C(C(C)(C)C)C=C7)S5)CC4)[C@@H](O)[C@H]3O
Molecular Formula
C41H53N7O3S
Molecular Weight
723.97
References & Citations
[1]Sethy B, et al. Design, synthesis, and biological evaluation of adenosine derivatives targeting DOT1L and HAT as anti-leukemia agents. Bioorg Chem. 2024 Sep 6;153:107771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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