S-2474

S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.

Product Specifications

CAS Number

[158089-95-3]

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/S-2474.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(C)(C)C)C=C(/C=C2CCN(CC)S\2(=O)=O)C=C1C(C)(C)C

Molecular Formula

C20H31NO3S

Molecular Weight

365.53

References & Citations

[1]Yagami T, et al. Effects of S-2474, a novel nonsteroidal anti-inflammatory drug, on amyloid beta protein-induced neuronal cell death. Br J Pharmacol. 2001 Oct;134 (3) :673-81.|[2]Yagami T, et al. S-2474, a novel nonsteroidal anti-inflammatory drug, rescues cortical neurons from human group IIA secretory phospholipase A (2) -induced apoptosis. Neuropharmacology. 2005 Aug;49 (2) :174-84. Epub 2005 Apr 1.