L 363851

L 363851 is a Neurokinin 2 receptor agonist, and induces the contractile response of tracheal smooth muscle devoid of epithelium (IC50 of 3.2 nM) and phosphoinositide hydrolysis (IC50 of 36 μM) .

Product Specifications

CAS Number

[100807-53-2]

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/l-363851.html

Smiles

CSCC[C@@H](C(N)=O)NC([C@@H](N1C([C@@H](CC1)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@@H]3CCC(N3)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC(C)C)=O

Molecular Formula

C38H51N7O7S

Molecular Weight

749.92

References & Citations

[1]Grandordy BM, et al. Tachykinin-induced phosphoinositide breakdown in airway smooth muscle and epithelium: relationship to contraction. Mol Pharmacol. 1988;33 (5) :515-519.