Recombinant Human CXCL10

12 months from date of receipt, -20°C to -70°C, as supplied. 1 month,- 20°C to -70°C, under sterile conditions after reconstitution. Best if used immediately after reconstitution. Avoid multiple freeze-thaw cycles.

CXCL10, also known as γ-interferon-inducible protein (IP-10), was originally identified as an IFN-gamma-inducible gene in endothelial cells, fibroblasts, and monocytes. IP-10 signals through the CXCR3 receptor to attract Th1 lymphocytes and monocytes. It also has angiostatic and mitogenic properties on vascular smooth muscle cells. A diverse population of cell types rapidly increases transcription of mRNA encoding IP-10, suggesting that IP-10 might be a key mediator of the IFN-gamma response.