Cirsilineol (Standard)

Cirsilineol (Standard) is the analytical standard of Cirsilineol. This product is intended for research and analytical applications. Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4+ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS) -induced T-cell-mediated experimental colitis in mice[1].

Product Specifications

CAS Number

[41365-32-6]

UNSPSC

12352005

Target

IFNAR; Reference Standards; STAT

Type

Reference Standards

Related Pathways

Immunology/Inflammation; JAK/STAT Signaling; Others; Stem Cell/Wnt

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cirsilineol-standard.html

Smiles

O=C1C=C(OC2=CC(OC)=C(C(O)=C12)OC)C3=CC=C(C(OC)=C3)O

Molecular Formula

C18H16O7

Molecular Weight

344.32

References & Citations

[1]Yang Sun, et al. Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease. Biochem Pharmacol. 2010 Jan 15;79 (2) :229-38.