N, N'-Dimethylthiourea

N, N'-Dimethylthiourea (DMTU), isolated from Allium sativum, is an orally active scavenger of hydroxyl radical (•OH) and blocks •OH production by activated neutrophils in vitro. N, N'-Dimethylthiourea protects against water-immersion restraint stress (WIRS) -induced gastric mucosal lesions in rats by exerting its antioxidant action including •OH scavenging and anti-inflammatory action[1][2].

Product Specifications

CAS Number

[534-13-4]

Product Name Alternative

DMTU

UNSPSC

12352211

Hazard Statement

H317

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-n-dimethylthiourea.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

S=C(NC)NC

Molecular Formula

C3H8N2S

Molecular Weight

104.17

Precautions

H317

References & Citations

[1]Yoshiji Ohta, et al. Protective effect of N, N'-dimethylthiourea against stress-induced gastric mucosal lesions in rats. Fundam Clin Pharmacol. 2017 Jun;31 (3) :319-328.|[2]Zhongyi Zhang, et al. Analysis of volatile compounds in fermented black garlic by GC-MS.