Adjudin
Adjudin is an extensively studied male contraceptive with a superior mitochondria-inhibitory effect. Adjudin is also a potent Cl- channel blocker.
Product Specifications
CAS Number
252025-52-8
Product Name Alternative
AF-2364
UNSPSC
12352005
Hazard Statement
H302
Target
Chloride Channel; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Adjudin.html
Purity
98.0
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
O=C(C1=NN(CC2=CC=C(Cl)C=C2Cl)C3=C1C=CC=C3)NN
Molecular Formula
C15H12Cl2N4O
Molecular Weight
335.19
Precautions
H302
References & Citations
[1]Li K, et al. Inhibition of sperm capacitation and fertilizing capacity by adjudin is mediated by chloride and its channels in humans. Hum Reprod. 2013 Jan;28 (1) :47-59.|[2]Li X, et al. Combination delivery of Adjudin and Doxorubicin via integrating drug conjugation and nanocarrier approaches for the treatment of drug-resistant cancer cells. J Mater Chem B. 2015 Feb 28;3 (8) :1556-1564.|[3]Xie QR, et al. Male contraceptive Adjudin is a potential anti-cancer drug. Biochem Pharmacol. 2013 Feb 1;85 (3) :345-55.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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