URB597

URB597 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH). FAAH is the enzyme that hydrolyzes anandamide (AEA) and other simple esters and amides with long unsaturated acyl chains (IC50 = 4.6 nM and 0.5 nM in brain membranes and intact neurons, respectively). URB597 displays both antinociceptive and anxiolytic effects in vivo without evoking other symptoms associated with cannabinoid-like compounds.