Nε- (Carboxymethyl) -L-lysine

Nε- (Carboxymethyl) -L-lysine (CML) is a unique post-translational modification (PTM) of proteins that is generated by the non-enzymatic glycation of lysine residues. Nε- (Carboxymethyl) -L-lysine is a relatively recently discovered modification, and has been found to be a major component of the advanced glycation endproducts (AGEs) found in multiple human diseases, such as diabetes, Alzheimer’s disease, and cancer[1].

Product Specifications

CAS Number

[5746-04-3]

Product Name Alternative

CML; N6- (Carboxymethyl) -L-lysine; Nε- (1-Carboxymethyl) -L-lysine

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nε-carboxymethyl-l-lysine.html

Purity

99.70

Solubility

H2O : 35 mg/mL (ultrasonic)

Smiles

C(CCNCC(=O)O)C[C@@H](C(=O)O)N

Molecular Formula

C8H16N2O4

Molecular Weight

204.22

Precautions

H315, H319, H335

References & Citations

[1]Fu MX, et al. The advanced glycation end product, Nepsilon- (carboxymethyl) lysine, is a product of both lipid peroxidation and glycoxidation reactions. J Biol Chem. 1996 Apr 26;271 (17) :9982-6